A Molecular View of HIV Therapy

After HIV enters a T-cell, three enzymes play essential roles in the life cycle of the virus. Reverse transcriptase copies the viral RNA genome and makes a DNA copy. Integrase inserts this viral DNA into the cell’s DNA. In the last steps of the viral life cycle, HIV protease cuts HIV proteins into their functional parts.

This animation was created based on atomic structures from the Protein Data Bank: Reverse Transcriptase: 3hvt, 3dlk, 3v6d, 3v4i, 3klg, 3v81 Integrase: 3os1, 3os0, 3oya Protease: 3pj6, 1kj4, 1hxb, 2az9, 2azc HIV Polyprotein, Capsid Protein, Matrix Protein: 1l6n, 2m8l, 1tam

Story: David S. Goodsell

Animation and Video Editing: Maria Voigt

Narration: Brian Hudson

Music: Gosta Berling

Postdoctoral position in RNA biology and Genomics in the Pelechano lab

Our collaborators in the Pelechano lab (Karolinska Institutet) are seeking for a postdoctoral fellow in RNA biology and genomics. The available postdoctoral position concerns developing and applying novel genomic approaches to study non-genetic heterogeneity in clonal population of cells. The candidate will focus on the study of translation regulation and its contribution to cell-to-cell variability in S. cerevisiae, with a special focus on ribosome dynamics, tRNA biology and post-transcriptional regulation. In a second stage the candidate will expand his/her work to the study of human cells. The candidate will perform original research in genomics, and acquire the required experimental and computational skills necessary for the completion of the project.

For the full information about this post visit the original job offer.

Postdoctoral position in Tim Nott’s lab

Our colleague Tim Nott offers a Wellcome Trust-funded postdoc position. The primary aim of the project is to understand the molecular basis and biochemical consequences of membraneless compartmentalisation in cells. The work will combine established methods of reconstituting membraneless organelles with the development of new biochemical assays and advanced microscopic imaging strategies.

Details of the post and how to apply can be found here:

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_details_form.jobspec?p_id=127299

The closing date for applications is 22 February 2017.

 

 

Two postdoctoral positions in RNA biology at the Vasilieva’s lab

Two postdoctoral positions are available early 2017 in the laboratory of  our collaborator Lidia Vasiljeva, who is funded by Senior Research Fellowship from the Wellcome Trust. Her lab is at the Department of Biochemistry, which is a part of the University of Oxford’s thriving scientific community. The Vasilieva lab is located in a new building providing interactive environment and various top class research facilities.

They are looking for highly motivated candidates with an interest in gene regulation in yeast and mammalian cells. The proposed projects will utilize state-of-the-art biochemistry and structural approaches combined with the functional genome-wide analysis to understand how transcription factors and chromatin modifiers regulate transcription of protein-coding and non-coding genesis in yeast and mammalian cells. The structural study will be done as a part of existing productive collaboration with Jonathan Grimes laboratory at STRUBi (Oxford). Candidates trained in protein purification, RNA analysis, and mammalian cell culture are encouraged to apply. Basic knowledge of bioinformatics is beneficial. Applicants should have or will shortly obtain a PhD and are expected to be highly motivated, with excellent critical thinking skills and with good communication skills and have the ability to work as part of a team.
Interested applicant should contact Dr Lidia Vasilieva directly:

Dr. Lidia Vasiljeva: lidia.vasilieva@bioch.ox.ac.uk
Lab web site: http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=675
phone:(+44)-1865613352