Postdoctoral Research Scientist – Genetics/Genomics

Our collaborators of the Bond lab are seeking an enthusiastic and motivated Postdoctoral Research Scientist in Genetics/Genomics to carry out cellular and organismal modelling of human genetic variants that affect cancer using cutting edge gene editing techniques.

You will have the opportunity to work on an exciting multi-disciplinary project and in close collaboration with bioinformaticians, clinicians and other groups within the university. The Postdoctoral Research Scientist in Genetics/Genomics role will be suitable for any graduate who is interested in utilising genetic, cellular and biochemical techniques to explore the interaction between genetics and environmental stresses and to determine how these interactions affect cellular fates.

In your role, as Postdoctoral Research Scientist in Genetics/Genomics, you will possess experience managing cancer genetics projects in vivo models, as well as possessing experience in ex-vivo cell culture assays. Previous laboratory experience, good communication skills, and the ability to work as part of a team are essential, along with an excellent track record for publishing and presenting scientific discoveries.

A detailed understanding of the molecular mechanisms behind tumourigenesis is crucial, along with the ability to carry out a wide range of molecular and cellular biology techniques, as well as basic and advanced in vivo techniques relevant to cancer research. You will hold a PhD degree in cancer genetics/genomics or be near to completion.

You will also be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post.

For more information visit:

Postdoctoral Position in Hematology, RNA Biology and Iron Metabolism

The Lab of Dr Mayka Sanchez at IJC (Barcelona) is looking for an enthusiastic postdoctoral candidate, who wants to work in a young and efficient team to address new and challenging aspects of haematology, RNA Biology and iron metabolism. The selected candidate will apply for salary funds from Generalitat Catalunya for a postdoctoral position.

Selection criteria

– Compulsory: Promising track record of early achievements, including significant publications (as main author, impact factor >6) in major international peer reviewed scientific journals.
– International mobility will be a plus.
– Proven Laboratory experience especially in haematology, microscopy, RNA Biology, mouse work, and/or iron biology.
– Good communication skills
– Languages: English (required), Spanish (helpful).


– 3-year postdoctoral contract. Additional expenses connected to the project are provided.
– Starting: From January 2017

How to apply
Please send your application to before 28th October 2016. Please include:
– Subject of email: Candidate Postdoc-2016
– A CV including your contact details and it is compulsory to include your publications and Impact Factor and provide detailed information concerning fulfilling of criteria
– Names of two referees (with email and phone number)

Joining our lab

We are always seeking for talented and motivated postdocs, graduate and master students.

20160523_131432Postdoctoral associates

Fully funded postdoctoral positions (if any) are advertised here and at the Biochemistry website.  If none is available, we are happy to advise outstanding candidates in their applications to postdoctoral fellowships. To be successful in such applications, the candidate should have an excellent track record, including publications in peer-reviewed journal as first authors. Fellowships available include Marie Sklodowska-Curie, EMBO long-term fellowship, Newton International Fellowship and Sir Henry Wellcome Postdoctoral Fellowship. Fellowships from the candidate’s country are also an option to explore.

DPhil/PhD students

The Department of Biochemistry and the University of Oxford offer highly competitive and prestigious scholarships to carry out a DPhil (PhD) in one of the most vibrant scientific environments in the world. These scholarships are given through DPhil programmes that are grouped based on research focus and interests (more information here). Our laboratory is associated  to (and thus eligible from) three DPhil programmes: Biochemistry, DTP BBSRC and WT Chromosome & Developmental Biology. Students with strong CV are encouraged to apply. Selection process takes into consideration bachelor and/or master grades as well as previous research experience.

Master students

The Department of Biochemistry also offers a prestigious master programme, referred to as master by research. This 2-year programmes does not include scholarship and thus students should either be self-funded or should obtain a scholarship from other source. We expect the student to have excellent bachelor grades and some lab experience.

Don’t hesitate to contact us ( for more information.

Discovering protein smartphones


New technique invented by EMBL researchers reveals uncharted docking sites in RNA-binding proteins

Some proteins are less like landlines and more like smartphones: they can do more than just talk to other proteins. One molecular app of particular interest is the ‘RNA-binding domain’, which lets proteins engage with RNA and influence how a cell responds to its environment. Lots of proteins use it – even ones that do not appear to have one. So how do you find an app that is clearly in use but has an invisible launch site? Researchers at EMBL invented a technique to do just that. Called RBDmap, the new method was recently published in Molecular Cell.

“We are one step closer to understanding how RNA and proteins interact,” says Matthias Hentze, who led the study.

Decades of research in the RNA field confirmed that proteins of a certain architecture can bind to RNA. But when the Hentze lab systematically searched for proteins that are able to bind to RNA using next generation methods, they saw something surprising: many of the proteins they discovered did not have any signature that could explain their RNA-binding ability. And yet, these enigmRBPs – as they came to be called – could still bind to RNA. But how? And why?

We are one step closer to understanding how RNA and proteins interact

In order to answer these questions, the EMBL scientists first needed to figure out which part of these enigmatic proteins does the binding in the first place. That’s where RBDmap comes in.

Think of RNA-binding proteins as people holding onto a single rope – a strand of RNA. The hands holding the rope represent the part of the protein that can interact with RNA, while the rest of the body is free to do something else. “RBDmap separates the hands from the rest of the body and identifies what these hands are and to whom they belong,” explains Alfredo Castello, who developed the technique as a staff scientist in Hentze’s lab. “It tells us exactly what part of the protein binds to RNA.”

Using this new approach, Hentze, Castello and colleagues mapped over one thousand previously unrecognised RNA-binding sites within 529 proteins. With this information, the researchers look forward to investigating how these RNA-binding proteins work. “If we can change a very small part of the protein, chances are it can no longer bind to RNA,” Hentze said. “But, the protein can still do its other jobs – which may be vital for the cell’s survival,” Hentze said. From these mutations, the researchers can begin to investigate the role of RNA binding in how cells respond to physiological stresses such as starvation and disease.