After HIV enters a T-cell, three enzymes play essential roles in the life cycle of the virus. Reverse transcriptase copies the viral RNA genome and makes a DNA copy. Integrase inserts this viral DNA into the cell’s DNA. In the last steps of the viral life cycle, HIV protease cuts HIV proteins into their functional parts.
This animation was created based on atomic structures from the Protein Data Bank: Reverse Transcriptase: 3hvt, 3dlk, 3v6d, 3v4i, 3klg, 3v81 Integrase: 3os1, 3os0, 3oya Protease: 3pj6, 1kj4, 1hxb, 2az9, 2azc HIV Polyprotein, Capsid Protein, Matrix Protein: 1l6n, 2m8l, 1tam
Story: David S. Goodsell
Animation and Video Editing: Maria Voigt
Narration: Brian Hudson
Music: Gosta Berling
Our collaborators in the Pelechano lab (Karolinska Institutet) are seeking for a postdoctoral fellow in RNA biology and genomics. The available postdoctoral position concerns developing and applying novel genomic approaches to study non-genetic heterogeneity in clonal population of cells. The candidate will focus on the study of translation regulation and its contribution to cell-to-cell variability in S. cerevisiae, with a special focus on ribosome dynamics, tRNA biology and post-transcriptional regulation. In a second stage the candidate will expand his/her work to the study of human cells. The candidate will perform original research in genomics, and acquire the required experimental and computational skills necessary for the completion of the project.
For the full information about this post visit the original job offer.
Our colleague Tim Nott offers a Wellcome Trust-funded postdoc position. The primary aim of the project is to understand the molecular basis and biochemical consequences of membraneless compartmentalisation in cells. The work will combine established methods of reconstituting membraneless organelles with the development of new biochemical assays and advanced microscopic imaging strategies.
Details of the post and how to apply can be found here:
The closing date for applications is 22 February 2017.
Two postdoctoral positions are available early 2017 in the laboratory of our collaborator Lidia Vasiljeva, who is funded by Senior Research Fellowship from the Wellcome Trust. Her lab is at the Department of Biochemistry, which is a part of the University of Oxford’s thriving scientific community. The Vasilieva lab is located in a new building providing interactive environment and various top class research facilities.
They are looking for highly motivated candidates with an interest in gene regulation in yeast and mammalian cells. The proposed projects will utilize state-of-the-art biochemistry and structural approaches combined with the functional genome-wide analysis to understand how transcription factors and chromatin modifiers regulate transcription of protein-coding and non-coding genesis in yeast and mammalian cells. The structural study will be done as a part of existing productive collaboration with Jonathan Grimes laboratory at STRUBi (Oxford). Candidates trained in protein purification, RNA analysis, and mammalian cell culture are encouraged to apply. Basic knowledge of bioinformatics is beneficial. Applicants should have or will shortly obtain a PhD and are expected to be highly motivated, with excellent critical thinking skills and with good communication skills and have the ability to work as part of a team.
Interested applicant should contact Dr Lidia Vasilieva directly:
Dr. Lidia Vasiljeva: email@example.com
Lab web site: http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=675
Our collaborators of the Bond lab are seeking an enthusiastic and motivated Postdoctoral Research Scientist in Genetics/Genomics to carry out cellular and organismal modelling of human genetic variants that affect cancer using cutting edge gene editing techniques.
You will have the opportunity to work on an exciting multi-disciplinary project and in close collaboration with bioinformaticians, clinicians and other groups within the university. The Postdoctoral Research Scientist in Genetics/Genomics role will be suitable for any graduate who is interested in utilising genetic, cellular and biochemical techniques to explore the interaction between genetics and environmental stresses and to determine how these interactions affect cellular fates.
In your role, as Postdoctoral Research Scientist in Genetics/Genomics, you will possess experience managing cancer genetics projects in vivo models, as well as possessing experience in ex-vivo cell culture assays. Previous laboratory experience, good communication skills, and the ability to work as part of a team are essential, along with an excellent track record for publishing and presenting scientific discoveries.
A detailed understanding of the molecular mechanisms behind tumourigenesis is crucial, along with the ability to carry out a wide range of molecular and cellular biology techniques, as well as basic and advanced in vivo techniques relevant to cancer research. You will hold a PhD degree in cancer genetics/genomics or be near to completion.
You will also be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post.
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