The Castello lab will move to the Centre of Virus Research (CVR), in the University of Glasgow, between Nov 2020 and July 2021. The CVR is home to the UK’s largest critical mass of virology researchers, co-located in a purpose-built centre with state-of-the art facilities and infrastructure. New research activities will be based at the CVR, including new PhD and Msc projects.
The CVR research covers emerging viruses, chronic infections , innate and intrinsic immunity , viruses and cancer, structural virology, viral genomics and bioinformatics.
The CVR is a member of the COVID-19 genomics UK consortium, which is currying out critical research to follow the expansion of SARS-Cov-2 and the consequent evolution of its genome. The CVR contribution to combat COVID-19 pandemics spans different lines of research, including virus tracking, characterisation and surveillance, as well as development of critical toolkit to enable UK research in SARS-Cov-2.
Jess and Morgan have worked in their part II projects for near six months in the Castello lab. They have studied different aspects of HIV biology by using cutting edge RNA biology, virology, molecular biology and microscopy techniques. Morgan has developed a new approach to elucidate the composition of the HIV ribonucleoproteins. Jess has assessed whether cellular RNA-binding proteins are incorporated into HIV particles. We hope they enjoyed working in the lab and wish them all the best for the coming scientific challenges.
Leslie worked in the Castello lab for five months as part of her degree in Princeton. She was interested in the understanding the role of a family of tumour suppressors recently classified as RNA-binding proteins by RNA interactome studies.
“Applying for this semester-long research opportunity at Oxford is one of the best decisions I have made at Princeton! I am constantly intellectually stimulated and challenged by my research project and my PI’s thoughtful feedback – said Leslie-. In my lab’s supportive environment, I have come to really appreciate microscopy, beautiful silver staining/Western blot gels, the satisfying popping sound in the homogenizing process of my RNA interactome capture whole cell lysates, and so much more! Would definitely consider coming back for grad school!”