The Castello lab will move to the Centre of Virus Research (CVR), in the University of Glasgow, between Nov 2020 and July 2021. The CVR is home to the UK’s largest critical mass of virology researchers, co-located in a purpose-built centre with state-of-the art facilities and infrastructure. New research activities will be based at the CVR, including new PhD and Msc projects.
The CVR research covers emerging viruses, chronic infections , innate and intrinsic immunity , viruses and cancer, structural virology, viral genomics and bioinformatics.
The CVR is a member of the COVID-19 genomics UK consortium, which is currying out critical research to follow the expansion of SARS-Cov-2 and the consequent evolution of its genome. The CVR contribution to combat COVID-19 pandemics spans different lines of research, including virus tracking, characterisation and surveillance, as well as development of critical toolkit to enable UK research in SARS-Cov-2.
RBPs are key key drivers of gene expression by controlling RNA fate. However, our knowledge about RBPs in plants is very limited. I our recent work, we report an improved RNA interactome capture approach to discover RNA-binding proteins (RBPs) in plant leaves . Using this ‘plant-adapted RNA interactome capture’ (ptRIC) we have identified hundreds novel RBPs, including many enzymes and proteins from the photosynthetic apparatus. ptRIC did not only allowed the generation of the deepest ‘RBPome’ of plant tissue to date, but also opens the possibility to study how the RBPome remodels in response to environmental, physiological and pathological cues.
This work is an interdisciplinary collaborative effort between the Castello lab (Department of Biochemistry) and Preston lab (Department of Plant Sciences) at the University of Oxford. Find out more about this work here:
Our colleagues from the Gallego lab in Barcelona, are now recruiting a Postdoc and a PhD position.
Oriol Gallego works at the interface between Cell Biology and Structural Biology, and aims to resolve biological mechanisms driving cell growth. His group develop new intracellular nanotools that help to enhance the resolutive power of live-cell imaging. This toolbox allows to answer biological questions that could not be tackled by other means. They have a brand new lab and equipment. The Gallego lab is based PRBB, an excellent research center in Barcelona, which is equipped with state-of-the-art facilities and with a highly international scientific environment. They seek for a Postdoc with expertise in quantitative live-cell microscopy (ideally, a microscopist with background in biophysics, optical physics or image analysis) and a PhD student (background in life-sciences, ideally with expertise in biophysics, biochemistry, structural biology or bioinformatics) to join our lab. Please, see the links for more details on the Postdoc and the PhD positions and visit www.gallegolab.org.
This scholarship will allow you to work in a multidisciplinary team between Prof. Ilan Davis (Microscopy and brain development), Alfredo Castello (RNA biology and viruses) and Martin Booth (Industrial partner Aurox.ltd).
Combining these expertise, we will build an affordable very fast confocal microscope with a small footprint, dedicated to prolonged live cell imaging of explanted brains in 3D, as well as to rapid 3D imaging of multiple single RNA molecules. Once built the microscope will have many applications. Depending on the background of the student, the work will involve a balance of optical engineering / biological experiments / data analysis. The student will have access to world leading training and collaborations through Micron Oxford to all the relevant expertise required for these three disciplines.
Our colleague, Claudia Ribeiro, is seeking for a motivated postdoc to work to work in the Babraham Institute (Cambridge) on the role of RNA-binding proteins in B lymphocyte development. For more information about the post visit here.