In their memory

With incredible sadness I received the terrible news that my colleagues and friends, Bernd Fischer and Katrin Eichelbaum, passed away. Bernd, Katrin and I formed a highly interdisciplinary team working at EMBL in Heidelberg from 2009 to 2014. Together with other colleagues at EMBL, we achieved a long-standing challenge: the determination of the “near complete” atlas of human RNA-binding proteins. Katrin and Bernd were outstanding scientists and great friends.

I can only be grateful for having the opportunity to work with you. You are terribly missed.

Alfredo

Bernd Fischer

Katrin Eichelbaum

 

 

Celebrating our great success!

Explaining me why ENSEMBL IDs?

A Molecular View of HIV Therapy

After HIV enters a T-cell, three enzymes play essential roles in the life cycle of the virus. Reverse transcriptase copies the viral RNA genome and makes a DNA copy. Integrase inserts this viral DNA into the cell’s DNA. In the last steps of the viral life cycle, HIV protease cuts HIV proteins into their functional parts.

This animation was created based on atomic structures from the Protein Data Bank: Reverse Transcriptase: 3hvt, 3dlk, 3v6d, 3v4i, 3klg, 3v81 Integrase: 3os1, 3os0, 3oya Protease: 3pj6, 1kj4, 1hxb, 2az9, 2azc HIV Polyprotein, Capsid Protein, Matrix Protein: 1l6n, 2m8l, 1tam

Story: David S. Goodsell

Animation and Video Editing: Maria Voigt

Narration: Brian Hudson

Music: Gosta Berling

Postdoctoral position in RNA biology and Genomics in the Pelechano lab

Our collaborators in the Pelechano lab (Karolinska Institutet) are seeking for a postdoctoral fellow in RNA biology and genomics. The available postdoctoral position concerns developing and applying novel genomic approaches to study non-genetic heterogeneity in clonal population of cells. The candidate will focus on the study of translation regulation and its contribution to cell-to-cell variability in S. cerevisiae, with a special focus on ribosome dynamics, tRNA biology and post-transcriptional regulation. In a second stage the candidate will expand his/her work to the study of human cells. The candidate will perform original research in genomics, and acquire the required experimental and computational skills necessary for the completion of the project.

For the full information about this post visit the original job offer.

Postdoctoral position in Tim Nott’s lab

Our colleague Tim Nott offers a Wellcome Trust-funded postdoc position. The primary aim of the project is to understand the molecular basis and biochemical consequences of membraneless compartmentalisation in cells. The work will combine established methods of reconstituting membraneless organelles with the development of new biochemical assays and advanced microscopic imaging strategies.

Details of the post and how to apply can be found here:

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_details_form.jobspec?p_id=127299

The closing date for applications is 22 February 2017.