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Positions available in the Gallego lab

Our colleagues from the Gallego lab in Barcelona, are now recruiting a Postdoc and a PhD position.

Oriol Gallego works at the interface between Cell Biology and Structural Biology, and aims to resolve biological mechanisms driving cell growth. His group develop new intracellular nanotools that help to enhance the resolutive power of live-cell imaging. This toolbox allows to answer biological questions that could not be tackled by other means. They have a brand new lab and equipment. The Gallego lab is based PRBB, an excellent research center in Barcelona, which is equipped with state-of-the-art facilities and with a highly international scientific environment. 
They seek for a Postdoc with expertise in quantitative live-cell microscopy (ideally, a microscopist with background in biophysics, optical physics or image analysis) and a PhD student (background in life-sciences, ideally with expertise in biophysics, biochemistry, structural biology or bioinformatics) to join our lab. Please, see the links for more details on the Postdoc and the PhD positions and visit www.gallegolab.org.

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iCASE scholarship (PhD/DPhil) to elucidate how the brain develops

This scholarship will allow you to work in a multidisciplinary team between Prof. Ilan Davis (Microscopy and brain development), Alfredo Castello (RNA biology and viruses) and Martin Booth (Industrial partner Aurox.ltd).

Combining these expertise, we will build an affordable very fast confocal microscope with a small footprint, dedicated to prolonged live cell imaging of explanted brains in 3D, as well as to rapid 3D imaging of multiple single RNA molecules. Once built the microscope will have many applications. Depending on the background of the student, the work will involve a balance of optical engineering / biological experiments / data analysis. The student will have access to world leading training and collaborations through Micron Oxford to all the relevant expertise required for these three disciplines.

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Discovering the cellular RNA-binding proteins controlling virus infection

Our new research published in Molecular Cell has uncovered that virus infection rewires cellular RNA-binding proteins (RBPs) on a global level. This reflects two antagonistic processes: the virus hijacking key cellular resources and the antiviral defence mechanisms of the cell. We discovered dozens of RBPs that play central roles in virus infection and opens new avenues for the development of antiviral therapies. Find out more about this work here.

Original article

System-wide profiling of RNA-binding proteins uncovers key regulators of virus infection. Garcia-Moreno M*,  Noerenberg M*, Ni S*,  Järvelin AI, González-Almela E, Lenz CE, Bach-Pages M, Cox V, Avolio R, Davis T, Hester S, Sohier TJM, Li B, Heikel G, Michlewski G,  Sanz MA, Carrasco L, Ricci EP, Pelechano V, Davis I, Fischer B, Mohammed S and Castello A. Molecular Cell. DOI: https://doi.org/10.1016/j.molcel.2019.01.017
https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30037-1