Viruses rely on cellular RNA-binding proteins (RBPs) to replicate. However, it remains unknown which cellular RBPs contribute to infection and how they do so. Our goal is to discover the complement of cellular RBPs required for virus infection and understand the mechanisms underpinning their regulatory roles. We envision that these cellular proteins will hold great potential as antiviral targets.
Our research combines a broad range of techniques, including RNA biology, virology, fluorescence and electron microscopy, flow cytometry, proteomics, genomics and computational biology. This multidisciplinary research is enhanced by the vibrant and collaborative atmosphere of the lab, the outstanding facilities of the Department of Biochemistry of the University of Oxford as well as local and international collaborators with complementary expertise.