The German Cancer Research Center (DKFZ) in Heidelberg, Germany, invites application for a highly motivated and creative PhD student to explore the molecular bases underlying metabolic reprogramming in cancer.
Cancer cells display profound metabolic alterations that enable them to meet the metabolic needs required for various aspects of malignancy. Understanding this metabolic remodeling is essential to decipher the fundamental mechanisms of tumorgenesis, as well as to find novel therapeutic solutions. Iron is a trace element important for many cellular functions and like other metabolic pathways, iron homeostatic mechanisms are frequently altered in cancer (Torti and Torti, Nat. Rev. Cancer, 2013).
In this project, we will make use of state-of-the-art tumor mouse models together with organoid cultures and various cell and molecular biology approaches to investigate the role of central regulatory networks of iron homeostasis in tumor biology, with a particular interest for intestinal cancers.
Applicants should hold a masters’ degree (or equivalent) in biology, biochemistry or related field, with an excellent background in tumor biology and a strong experience in cell and molecular biology techniques; experience in mouse models would be advantageous. The student shall be committed, enthusiastic, rigorous and goal oriented. The candidate shall be very well organized, have excellent communication and writing skills, and be able to work both independently and in a team environment.
Please send your CV, copies of certificates, transcript of records from Bachelor’s and Master’s studies, your research interests and contact addresses of two referees.