Postdoctoral position in RNA biology and metabolism – DKFZ Heidelberg

The German Cancer Research Center (DKFZ) invites application for a highly motivated and creative postdoctoral researcher to explore the molecular bases of metabolic and genetic regulations. The DKFZ is located in the picturesque city of Heidelberg in the South of Germany and benefits from an exceptionally strong research environment, with Germany’s oldest university and several other leading life science research institutions in Europe.  The  successful  candidate  will  join  the  lab  of  Dr.  Bruno  Galy  in  the  „virus-­‐ associated carcinogenesis unit“.

Metabolic remodeling is emerging as a key process of physiology and disease. Although posttranscriptional regulations play a key role in shaping proteomes, genetic control of metabolism has so far been mostly investigated at the level of transcription. The interconnection between metabolism and the complex life of a mRNA, from its synthesis to its translation and decay, thus remains poorly understood. Iron metabolism is ideally suited   to   study   the   posttranscriptional   regulation   of   metabolism.   Indeed,   iron homeostasis is maintained by two RNA binding factors called Iron Regulatory Proteins (IRPs), which modulate the translation or turnover of target mRNAs. In this postdoctoral project, we will use high-­‐throughput technologies developed recently to define the regulatory scope of the IRP network on a system wide scale. This integrative approach will be carried out in vivo, using state-­‐of-­‐the-­‐art  IRP mouse models. With this work we wish to unveil new facets of a central homeostatic circuit in the cell, and constitute a basis for the study of other gene regulatory networks with similar properties.

The applicant holds a Ph.D. (or equivalent degree) in biology, biochemistry or related field  and  an  excellent  publication  record.  He/She  is  expected  to  have  a  strong background  in  RNA  biology.  A  solid  experience  with  cell  and  molecular  biology techniques and in particular high throughput approaches will be essential; familiarity with standard bioinformatical analysis of large data sets is also required. The candidate is rigorous, able to conduct independent research, but also enjoys interacting with colleagues of different disciplines and nations. Good presentation skills and experience on project management (importance of scheduling, deliverables, reporting) will be highly valued.

Funding for a total of 3 years is available and the position is open immediately. Your application (in English language) must include a CV, a summary of academic records, your research interests, and at least two letters of recommendation (or contact details of potential referees). For further question, please contact Dr. Bruno Galy (b.galy@dkfz.de).

PhD Student in the area of cancer metabolism – Galy lab, DKFZ, Heidelberg

The German Cancer Research Center (DKFZ) in Heidelberg, Germany, invites application for a highly motivated and creative PhD student to explore the molecular bases underlying metabolic reprogramming in cancer.

Cancer cells display profound metabolic alterations that enable them to meet the metabolic needs required for various aspects of malignancy. Understanding this metabolic remodeling is essential to decipher the fundamental mechanisms of tumorgenesis, as well as to find novel therapeutic solutions. Iron is a trace element important for many cellular functions and like other metabolic pathways, iron homeostatic mechanisms are frequently altered in cancer (Torti and Torti, Nat. Rev. Cancer, 2013).

In this project, we will make use of state-of-the-art tumor mouse models together with organoid cultures and various cell and molecular biology approaches to investigate the role of central regulatory networks of iron homeostasis in tumor biology, with a particular interest for intestinal cancers.

Profile

Applicants should hold a masters’ degree (or equivalent) in biology, biochemistry or related field, with an excellent background in tumor biology and a strong experience in cell and molecular biology techniques; experience in mouse models would be advantageous. The student shall be committed, enthusiastic, rigorous and goal oriented. The candidate shall be very well organized, have excellent communication and writing skills, and be able to work both independently and in a team environment.

Please send your CV, copies of certificates, transcript of records from Bachelor’s and Master’s studies, your research interests and contact addresses of two referees.

ADDITIONAL INFORMATION

http://www.dkfz.de/en/stellenangebote/index.php?id=090/2016