Recently, two independents works published in Nature Com and NSMB have shown the unexpected complexity of the repertoire of RNA-binding proteins in both S. cerevisiae and C. Elegans. Strikingly, metabolic enzymes and other enzymatic cores arise as enigmatic RNA-binders from yeast to human, suggesting either surprising and conserved roles of these proteins in post-transcriptional control of gene expression or a widespread function of RNA as regulator of enzymatic activities.
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The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs.
Benedikt M. Beckmann, Rastislav Horos, Bernd Fischer, Alfredo Castello, Katrin Eichelbaum, Anne-Marie Alleaume, Thomas Schwarzl, Tomaž Curk, Sophia Foehr, Wolfgang Huber, Jeroen Krijgsveld & Matthias W. Hentze
Conserved mRNA-binding proteomes in eukaryotic organisms
Ana M Matia-González, Emma E Laing & André P Gerber