Ph.D. position in cancer metabolism (DKFZ, Heidelberg)

Research group: “Metabolism of Infection/Inflammation-induced Cancer” (F170)

German Cancer Research Center (DKFZ), Heidelberg, Germany

Bruno Galy’s lab invites application for a highly motivated and creative Ph.D. student to explore the molecular bases underlying metabolic reprogramming in cancer.
Cancer cells display profound metabolic alterations that enable them to meet the metabolic needs required for various aspects of malignancy. Understanding this metabolic remodeling is essential to decipher the fundamental mechanisms of tumorigenesis, as well as to find novel therapeutic solutions. Iron is a trace element important for many cellular functions and like other metabolic pathways, iron homeostatic mechanisms are frequently altered in cancer (Torti and Torti, Nat. Rev. Cancer, 2013). In this project, we will make use of state-of-the-art tumor mouse models together with organoid cultures and various cell and molecular biology approaches to investigate the role of central regulatory networks of iron homeostasis in tumor biology, with a particular interest for intestinal cancers.
Applicants should hold a masters’ degree (or equivalent) in biology, biochemistry or related field, with an excellent background in tumor biology and a strong experience with cell and molecular biology techniques and mouse models. The student shall be committed, enthusiastic, rigorous and goal oriented. The candidate shall be very well organized, have excellent communication and writing skills, and be able to work both independently and in a team environment.
Please send your CV, copies of certificates, transcript of records from Bachelor’s and Master’s studies, your research interests and contact addresses of two referees to Dr. Bruno GALY (b.galy@dkfz.de).

Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins

In the past century, few areas of biology advanced as much as our understanding of the pathways of intermediary metabolism. Initially considered unimportant in terms of gene regulation, crucial cellular fate changes, cell differentiation, or malignant transformation are now known to involve ‘metabolic remodeling’ with profound changes in the expression of many metabolic enzyme genes. This review focuses on the recent identification of RNA-binding activity of numerous metabolic enzymes. We discuss possible roles of this unexpected second activity in feedback gene regulation (‘moonlighting’) and/or in the control of enzymatic function. We also consider how metabolism-driven post-translational modifications could regulate enzyme-RNA interactions. Thus, RNA emerges as a new partner of metabolic enzymes with far-reaching possible consequences to be unraveled in the future.

 

http://www.sciencedirect.com/science/article/pii/S1043276015001952